L-methionine is usually isolated from the DL-methionine produced .
This is done with an isolated enzyme of microbial origin. The enzyme attaches to L-methionine. This specificity allows the two to be separated by ordinary chemical means. The enzyme is the treated (I’m thinking with acid base chemistry) to release the L-methionine product. The enzyme is re-usable.
The D-methionine half (which may be altered by the isolation process) can be used as for whatever purpose or destroyed. There are methods to convert D-methionine to DL-methionine again (to be added back into the previous separation process), L-methionine could also be converted to DL-methionine. That conversion is not 100% racemic yield.
On the industrial plant equipment level this operation is not costly to invest in, by any means. Nor is it energy intensive. It is not labor intensive. It is a process that has been in place on the industrial level for some time.
At quoted prices, L-methionine will likely cost twice as much because it comes from DL-methionine.
L-methionine is the only assimilable isomer that does not require an unnatural conversion, over excretion, or, execrative metabolism. D-methionine may become involved preliminarily in some simple metabolic processes. It may be integrated accidentally into proteins, in effect denaturing those proteins to varying degrees.
Exactly how D-methionine is handled by mammalian systems is not of scientific importance because naturally it would never happen.
Biological and medical science would be very interested in how L-methionine is utilized because it is involved as a critical process. SAMe is a common derivative.
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Lisa Zhang
lisazhang@unischem.com
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Ningxia Unisplendour Tianhua Methionine Co.,Ltd
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