Methionine is an essential amino acid in all animal species. Methionine is clearly recognised as the first limiting amino acid in poultry, and probably also in high-yielding cows, and as the second or third limiting amino acid in pigs fed conventional diets. Supplementation of appropriate amounts of methionine and methionine analogues to meet requirements is safe for the target species. The earliest signs of a critical overdose are reduced feed intake and weight gain. The level of supplementary methionine and its analogues that is toxic varies from species to species and depends on the basal diet and its content of sulphur-containing amino acids.
Methionine from DL-Met and its hydroxy analogue and their salts is incorporated in the protein of tissues and products, showing a constant amino acid pattern. Consequently, the use of these additives will not result in an increased methionine content in tissues and products. Doses exceeding the requirement will be excreted.
Residues present in the animal tissues and products resulting from the extremely small quantities of free styrene and 2-vinylpyridine found in DL-Met-cop are very unlikely to raise concerns about consumer safety.
None of the products are considered to present a significant inhalation risk. DL-Met, DL-Met-cop and DL-Met-ec are considered non-irritant to skin and eyes, and the lack of sensitisation potential demonstrated for DL-Met is considered to apply also to DL-Met-cop and DL-Met-ec. DL-Met-Na is considered corrosive to skin and eyes and harmful if swallowed. HMTBa is an irritant to the skin and corrosive to the eyes but is not a dermal sensitiser. HMTBa-Ca is irritant to the eyes but not to the skin. The absence of a dermal sensitisation potential demonstrated for HMTBa is considered to apply also to HMTBa-Ca. HMTB-i is non irritant to the skin and eyes, and it is not a dermal sensitiser.
Ningxia Unisplendour Tianhua Methionine Co.,Ltd
Ningxia Unisplendour Tianhua Methionine Co., Ltd mainly deals in the research, production and sales of DL-Methionine. It is the only domestic producer of deed grade DL-Methionine. As the main shareholders, Chongqing Unisplendour Chemical Co.,Ltd is a leading chemical producer of HCN and its derivatives in China. With giant partnership between shareholders, the company makes a great contribution to promote good development of feed and livestock industry.
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Lisa Zhang
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