Indications for DL Methionine

Indications For enrichment and balancing of diets of farm animals, including birds, preparation of polnoratsionny compound feeds, premixes, feed additives. The pharmacological Methionine properties, being irreplaceable amino acid, plays an important role in a metabolism. He takes active part in synthesis of fabric proteins, and also processes of synthesis of a number of vitamins, hormones, enzymes that is caused by existence by slabosvyazanny metilny group (-CH3) which can pass into DNA, and is a universal source of metilny groups for all nucleinic acids. Also methionine directly influences hemoglobin synthesis, is necessary for synthesis of adrenaline, noradrenaline, a tsiankobalamin, creatinine, amide of nicotinic acid and some other the substances exerting impact on a nitrogenous, carbon and fatty exchange. Also together with cystine and vitamin A participates in formation of a feather at birds, together with cystine and vitamin E interferes with fatty regeneration of a liver. In comparison with a liquid metioningidroksianalog digestibility an animal organism (biological efficiency) of dry DL Methionine is about 35% higher. At a lack of methionine of an organism of animals and birds appetite loss, anemia, a muscles atrophy, liver obesity, dysfunction of kidneys, decrease in an oplodotvoryaemost, reduction in the rate of growth of young growth and efficiency of an adult bird, violation of plumage and an operyaemost at birds (a vzjeroshennost of feathers, their dullness, fragility and loss) is observed. Thereof low efficiency of use of forages is observed. Formation of egg white is slowed down and, respectively, the mass of eggs decreases. The violation of a lipidic exchange which is characterized by a fatty infiltration and dystrophy of a liver is noted. At a simultaneous lack of vitamin E deficiency of methionine leads to development of muscular dystrophy in chickens and dermatitis of legs. Thanks to high flowability and good miscibility the preparation is convenient in application, and, unlike a liquid metioningidroksianalog does not cause corrosion and wear of the equipment, is safe in the address and can be applied at any stage of preparation of a kormosmesa.

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DL Methionine feed grade Unisplendour Methionine

Methionine is an essential amino acid in all animal species. Methionine is clearly recognised as the first limiting amino acid in poultry, and probably also in high-yielding cows, and as the second or third limiting amino acid in pigs fed conventional diets. Supplementation of appropriate amounts of methionine and methionine analogues to meet requirements is safe for the target species. The earliest signs of a critical overdose are reduced feed intake and weight gain. The level of supplementary methionine and its analogues that is toxic varies from species to species and depends on the basal diet and its content of sulphur-containing amino acids.

Methionine from DL-Met and its hydroxy analogue and their salts is incorporated in the protein of tissues and products, showing a constant amino acid pattern. Consequently, the use of these additives will not result in an increased methionine content in tissues and products. Doses exceeding the requirement will be excreted.

Residues present in the animal tissues and products resulting from the extremely small quantities of free styrene and 2-vinylpyridine found in DL-Met-cop are very unlikely to raise concerns about consumer safety.

None of the products are considered to present a significant inhalation risk. DL-Met, DL-Met-cop and DL-Met-ec are considered non-irritant to skin and eyes, and the lack of sensitisation potential demonstrated for DL-Met is considered to apply also to DL-Met-cop and DL-Met-ec. DL-Met-Na is considered corrosive to skin and eyes and harmful if swallowed. HMTBa is an irritant to the skin and corrosive to the eyes but is not a dermal sensitiser. HMTBa-Ca is irritant to the eyes but not to the skin. The absence of a dermal sensitisation potential demonstrated for HMTBa is considered to apply also to HMTBa-Ca. HMTB-i is non irritant to the skin and eyes, and it is not a dermal sensitiser.

Ningxia Unisplendour Tianhua Methionine Co.,Ltd

Ningxia Unisplendour Tianhua Methionine Co., Ltd mainly deals in the research, production and sales of DL-Methionine. It is the only domestic producer of deed grade DL-Methionine. As the main shareholders, Chongqing Unisplendour Chemical Co.,Ltd is a leading chemical producer of HCN and its derivatives in China. With giant partnership between shareholders, the company makes a great contribution to promote good development of feed and livestock industry.

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Amino acids and intestinal health

A weaned piglets, intestinal broad reshaping occurs to shift to adapt to solid feed from the liquid feed. The stage adaptation of nutritionists constitute a significant challenge, they must consider how to help the transition to solid feed pigs, but also to meet the expected costs.

From the perspective of an amino acid, reduce intestinal pressure while reducing the cost of the diet is an important strategy is an amino acid added to reduce rations by reasonable crystalline crude protein content. Reducing the crude protein content reduces the amount of the large intestine can ferment proteins, which would reduce the incidence of post-weaning diarrhea. This will also reduce the demand for protein sources, such as soybean meal, which will constitute the intestinal immune challenges, while also reducing the amount of some expensive protein sources. Early weaned pigs total lysine levels often configured as 1.65 to 1.7% or higher. At low levels of lysine (1.35% standardized ileal digestible (SID) lysine or 1.5% of total lysine) can reduce the need for expensive protein sources, but on pig performance is small.

When the low-lysine diets SID when other amino acids relative to lysine ratio is very critical. Other amino acids relative to the proportion of lysine, methionine plus cysteine ​​was 58%, 62% threonine, valine 65%, isoleucine 52% (if the blood product usage is high, then the percentage should be 60%). Tryptophan ratio of lysine remains controversial, recommended ratio is between 16.5 to 20 percent, depending on the level of nutrients as well as the specific experiment. A particular amino acid (e.g. arginine or glycine, and glutamic acid) seem to be able to meet the needs of the non-essential amino acids, and for the development of the intestinal tract has the intended effect.

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Classification of amino acids in pig feed and its role

Amino acids are the basic unit composed of protein, it is divided into two major categories of essential and non-essential.

Essential amino acids the body can not be a hog or synthetic slow and can not meet the needs of pigs, it must be supplied by the diet.

The pigs required 10 kinds of essential amino acids, namely lysine, methionine, tryptophan, arginine, threonine, valine, histidine, leucine, isoleucine, phenylalanine .

Lysine, methionine, threonine and tryptophan are growing pig diets in the first four limiting amino acids. Pigs various stages of growth of these four kinds of amino acid requirements have been fully understood. The four mature crystalline amino acids and synthesis of synthetic technology has been able to meet the needs of commercial applications, and so that by adding synthetic amino acids. The typical corn - soybean meal crude protein content in pig diets reduced about 2%, the net can be increased by 2%. The study shows that, despite the low protein diet so that the carcass become fat trend. However, to maintain the original pig performance.

Ration of feed ingredients consisting of lysine present, egg + cystine, the relative lack of threonine, tryptophan, reducing the production of feed utilization and performance of animals. Therefore, you should add the appropriate amino acid in pig feed according to the type of diet.

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DL- Metionina

DL- Metionina , es sintetizado a partir de materias primas petroquímicas, usando un conocido proceso de carbonato 
Este sistema de prueba compleja da como resultado un producto de alta calidad sin la formación de residuos de sal, evitando así, en gran medida la contaminación por los residuos del aire y el agua.

Particularmente para uso en nutrición de animales monogástricos. DL Metionina de grado feed, asegura el suministro adecuado de aminoácidos azufrados, especialmente de la metionina esencial . Siendo la metionina el primer limitante en la dietas típicas de las aves de corral, su uso ha sido bien establecido por muchos años. El uso en las dietas para lechones y cerdos en crecimiento pueden mostrar una considerable eficiencia con la metionina, especialmente cuando es formulada para lograr excreción de baja de nitrógeno por razones ecológicas, tales deficiencias pueden ser convenientemente compensadas usando DL Metionina de grado feed.

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Methionine, DL Methionine, L Methionine

L-methionine is usually isolated from the DL-methionine produced .

This is done with an isolated enzyme of microbial origin. The enzyme attaches to L-methionine. This specificity allows the two to be separated by ordinary chemical means. The enzyme is the treated (I’m thinking with acid base chemistry) to release the L-methionine product. The enzyme is re-usable.
The D-methionine half (which may be altered by the isolation process) can be used as for whatever purpose or destroyed. There are methods to convert D-methionine to DL-methionine again (to be added back into the previous separation process),  L-methionine could also be converted to DL-methionine. That conversion is not 100% racemic yield.

On the industrial plant equipment level this operation is not costly to invest in, by any means. Nor is it energy intensive. It is not labor intensive. It is a process that has been in place on the industrial level for some time.
At quoted prices, L-methionine will likely cost twice as much because it comes from DL-methionine.

L-methionine is the only assimilable isomer that does not require an unnatural conversion, over excretion, or, execrative metabolism. D-methionine may become involved preliminarily in some simple metabolic processes. It may be integrated accidentally into proteins, in effect denaturing those proteins to varying degrees.

Exactly how D-methionine is handled by mammalian systems is not of scientific importance because naturally it would never happen.
Biological and medical science would be very interested in how L-methionine is utilized because it is involved as a critical process. SAMe is a common derivative.

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What are amino acids?

Twenty percent of the human body is made up of protein. Protein plays a crucial role in almost all biological processes and amino acids are the building blocks of it.

A large proportion of our cells, muscles and tissue is made up of amino acids, meaning they carry out many important bodily functions, such as giving cells their structure. They also play a key role in the transport and the storage of nutrients. Amino acids have an influence on the function of organs, glands, tendons and arteries. They are furthermore essential for healing wounds and repairing tissue, especially in the muscles, bones, skin and hair as well as for the removal of all kinds of waste deposits produced in connection with the metabolism.

The importance of amino acids for human well-being is on the increase

Meirion Jones, a well-known BBC journalist, reported that contrary to years ago, many doctors have now confirmed that a supply of amino acids (also by way of nutritional supplements) can have positive effects.

Jones and Erdmann explain the changes in medical opinion in the following way: “Unfortunately, in the real world countless factors are working to prevent our bodies from receiving a full and balanced supply of these all-important substances. Among these factors are the pollution caused by burning fossil-fuels, the hormones fed to cattle, the intensive use of fertilizers in agriculture, and even habits such as smoking and drinking, all of which can prevent our bodies from fully using what we eat. Worse still is the amount of nutrition that is lost from our food through processing before we actually get to eat it...By providing the body with optimal nutrition, amino acids help to replace what is lost and, in doing so, promote well-being and vitality.”

A recent study from Germany carried out by the DAK has revealed that older people in particular are more prone to suffering from malnutrition. “If the body is lacking in the minimum energy and nutrients, the body cannot carry out its bodily and mental functions. Without the necessary vitamins, proteins (amino acids), trace elements and minerals, there is a risk of debilities and metabolic disorders which can have serious consequences.”

The amino acid pool has to be right

Jones believes that almost every disease caused by civilisation is a result of imbalances in our metabolism. The amino-acid pool is jointly responsible for achieving a balanced metabolism.

The amino acid pool describes the entire amount of available free amino acids in the human body. The size of the pool amounts to around 120 to 130 grams in an adult male. If we consume protein in the diet, the protein in the gastro-intestinal tract is broken down into the individual amino acids and then put back together again as new protein. This complex biological process is called protein biosynthesis. The entire amino acid pool is transformed, or ‘exchanged’ three to four times a day. This means that the body has to be supplied with more amino acids, partly by protein biosynthesis, partly by the diet or through consumption of suitable dietary supplements.

The objective is that the amino acid pool is complete and maintained in the correct combination. If the one or more amino acids are not available in sufficient quantities, the production of protein is weakened and the metabolism may only function in a limited way.

Older people are not the only ones who this applies to, for young people can also be affected by the negative consequences of a limited supply of nutrients. These include weight problems, hair loss, skin problems, sleep disorders, mood swings and/or erectile disorders but also arthritis, diabetes, cardiovascular imbalance (high cholesterol levels, high blood pressure) or even menopausal complaints.

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Ningxia Unisplendour Tianhua Methionine Co.,Ltd

Ningxia Unisplendour Tianhua Methionine Co.,Ltd, estiblished in June 2013 and located in Zhong Wei industrial Park of Ningxia, is specialized mainly in technology development, manufacturing and sales of DL Methionine feed grade.

Its shareholder Chongqing Unisplendour Tianhua Methionine Co.,Ltd, was incoperated  and went into operation in June 2010 with annual output of 10 thousand tons, based on the demonstration plant of DL Methionine Feed Grade. At this point, the company became the only manufacture of DL Methionine Feed Grade in China and have made contributions to the sustained and healthy development of Chinese feed industry and stock reselling, and the further development of food consumption of 1.3 billion Chinese people.

The first project of methionine production in Ningxia Unisplendour Tianhua Methionine Co.,Ltd was completed in October 2014 and went into cooperation with annual output 50 thousands tons. The core competence of the company lies in the technological innovation and clean production technology from proprietary intellectual property rights. The company is committed to strict quality control and already qualified by ISO9001 and FAMI-QS system. Furthermore, it conscientiously fulfills its social responsibility, becomes an environmental friendly enterprise and builds the advanced "three wastes " treatment system.

The product of Ningxia Unisplendour Tianhua Methionine Co.,Ltd not only sales in the domestic market but also have already exported to more than 50 countries and region in the world. The second project will be put into production in the second half of 2016, by then annual output of methionine will amount to 100 thousand tons.

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DL Methionine Brief Introduction

DL-Methionine is biological protein synthesis skeleton amino acids. DL-Methionine is the necessary growth factors in livestock animal. It can also regulate animal’s metabolism. It is already widely used in feed, medicine, food and cosmetics, etc. In the feed industry, the maximum dosage is DL-Methionine. It is used to strengthen feed nutritional. If you add 1kg DL-Methionine in feed, and its nutritional value correspond to 50kg fish powder. DL-Methionine addition was 0.5%—0.2% in the feed. In the medicine area, DL-Methionine is the major element in aminophenol transfusion and compound amino acids. And also can used in synthetic medicinal vitamin. DL-Methionine has anti-fatty liver effects can be used to produce liver drug. In the food area, DL-Methionine is used for food’s amino acids and health food processing. And also used as nutrition supplement.

Storage: Store in a cool, dry, ventilated warehouse. When storing large goods, you should install conductive balance equipment, and prevent the accumulation of static electricity charge. Product should be prevented from solarization, humidity and rain. Strictly forbid with the toxic substances mix to luck.

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The concept of ideal protein

Amino acids which are essential cannot be synthesized by the animal and therefore must be provided by the diet. When the supply of one of these essential amino acids does not meet the animal’s requirement for this amino acid, it is said to be limiting. This limiting amino acid is limiting the potential growth of the animal. Once the limiting amino acid is covered via the feed, the next amino acid will become limiting (second limiting amino acid, third limiting amino acid, etc). Therefore the goal is to know the exact requirement of the animal for every essential amino acid in order to supply this amount to the animal via the diet. This is what is called the ideal protein concept. In practical diets, lysine is the first limiting amino acid. Therefore we always express the requirement of all essential amino acids as a ratio to lysine.

Amino acids can be supplied by the diet via feedstuffs (cereals, soybean meal, etc). The amino acid pattern (ratio of essential amino acids to lysine) in protein feedstuffs is not exactly in line with the requirement of the animal (the ideal protein). Protein feedstuffs are too low in the first limiting amino acids. If we would supply all essential amino acids via raw materials we would have to supply very high levels of crude protein. Because not all protein will be used, the surplus will be excreted by the animal. This surplus of protein has a negative impact on the animal’s health (surplus protein will be used by pathogenic bacteria in the large intestine and can cause intestinal disorders) and has a negative impact on the environment (nitrogen excretion).

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Methionine on the pros and cons of laying hens

It is very high productivity for Layers ,which produce eggs about four times the body weight  per year, so the nutrition and protein needed for laying hens is relatively high. According to calculations, there is about 16 grams of protein be needed for layers per day. Egg protein is quality protein, so amino acids used egg protein must  be well balanced, preferably similar to the whole egg protein. It must be supplemented with synthetic amino acids in that the amount of sulfur-containing amino acid is not enough which Usually with soybean meal and sorghum as the main raw material feed.


Methionine  is an essential amino acid in flaying hens feed , it promotes the growth of laying hens, increase the production of eggs, improve the efficiency of feed, increase the benefits of economy. But we should add the suitable amount of methionine becuase excessive layers metabolic disorders can cause illness.


Under normal circumstances, methionine absorbed by the Chicken body, under the action of various amino acids of enzymes, mainly in the liver, kidney decomposition, anabolic, into a protein, nitrogen and active substances for energy, growth and development for the body to use. Also, however, such excess methionine, methionine absorption into the liver exceeds the amount of decomposition of the liver, synthesis, decomposition normal anabolic is destroyed, resulting in the decomposition of toxic substances can not be excluded, accumulate in the liver, kidney, cause liver, kidney cell degeneration and swelling, causing hens metabolic balance disorders, poisoning. General layer feed already contains enough methionine, do not need to add, eager to encourage excessive addition, it will be counterproductive. Thus, feeding hens, must not blindly increase the methionine content in the feed.

Ningxia Unisplendour Tianhua Methionine Co.,Ltd is the only domestic manufacture of dl methionine in China. Our factory is located in Ningixa,China.

We are experienced in exporting dl methionine ever since 2009,which owns a professionsl R&D team with national standard for dl methionine quality control. Besides,We are the only domestic manufacture with an annual production capacity of 50,000 MT. And we have a profeesional sales team service for meeting with your requirments. And more, Our company are able to provide you a stable and sustainable supply.

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Why add methionine and lysine into pig feed

Now much of the world's farm takes corn - soybean meal in the diet,  lysine and methionine are the first and second limit amino acids for pigs, so it need to be add extraly.

Essential amino acids in pigs include lysine, methionine, tryptophan, phenylalanine, leucine, isoleucine, valine, threonine. Soybean meal is rich in lysine and tryptophan, methionine and corn containing more so with corn and soybean meal, amino acids complementary to achieve better nutritional balance.

Because of lack of essential amino acids, the protein synthesis reduce body, causing a series of body protein metabolism, enzymes synthesis problems, the most important manifestations of growth retardation, and even lead to metabolic diseases.

Lysine is mainly used for protein deposition, are rarely involved in the regulation of metabolic processes. The role of methionine complex, in addition to protein deposition, but also closely related to the in vivo metabolism of sulfur-containing compounds, in addition to also use its methyl brought on poisons or drugs played a role in methylation and detoxification.

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DL Methionine Specification

DL-Methionine is one of the limitiong amino acids required by poultry and livestock and a nutriment for high quality chicken and pork. It can also reduce the discharge of NH3 in livestock manure.

It is white or light grey crystal or powder with special smell. The density is 0.6g/cm³ and the melting point is 281 ℃. It can be soluble in water, low-concentration acid & alkali solution but ether.

Application:

(1). Meliorate the balance of amino acid for metabolism and supplement the insufficiency of         L-lysine in the feed stuff to promote the growth of livestock.

(2). Improve the meat quality of poultry and livestock.

(3). Reduce the possibility of diarrhea and help to digest.

(4). Enhance the body's immune ability, effective to avoid infectious disease.

Precautions:

1. Keep away from heat.

2. Keep away from sources of ignition.

3. Empty containers pose a fire risk, evaporate the residue under a fume hood.

4. Ground all equipment containing material.

5. Do not breathe dust. Wear suitable protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek medical attention and show the label when possible. Avoid contact with skin and eyes.

Specification of DL Methionine

Appearance: White Crystal or White Powder

Certificate: SGS ISO-9001/FAMI QS

Grade: 99% Feed Grade

Usage: Feed Preservatives, Promote Healthy & Growth, Promote Nutrition

Package: 25kgs Compound Bag

Package Size Per Piece: 575mm*525mm*145mm

Shelf life:5 years

Product type: Feed Grade Amino Acids

DL-Methionine(%): 99.0min

Loss on Drying(%):0.3max

Sodium Sulfate(Na2SO4)(%):0.5max

Sodium chloride(NaCI)(%):0.2max

Heavy Metal, Pb(mg/kg):1.0max

Arsenic(mg/kg):2.0max

Bulk Density(g/cm3):0.57-0.6

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What's the difference between D-Methionine and DL-methionine?

Methionine is a critical amino acid in the production of creatine. Creatine plays second string to the needs such as carnitine for the heart muscles. DL-methionine in the right mixture creates sort of starvation. Nothing is left for creatine production but the D-isomer, eating more introduces more D-isomer into the equation. 

L-methionine is the only assimilable isomer that does not require an unnatural conversion, over excretion, or, execrative metabolism. D-methionine may become involved preliminarily in some simple metabolic processes. It may be integrated accidentally into proteins, in effect denaturing those proteins to varying degrees. Exactly how D-methionine is handled by mammalian systems is not of scientific importance because naturally it would never happen.

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La méthionine

Dans sa forme naturelle, la L-méthionine est un acide aminé protéinogénique. Elle appartient au groupe des acides aminés essentiels, et ne peut pas être synthétisée par l'organisme. Par conséquent, un apport suffisant au travers de l'alimentation ou de compléments alimentaires est essentiel.

Des composants soufrés sont présents chez tous les êtres vivants, et présentent une grande variété de fonctions. En dehors de la cystéine, la méthionine est le seul acide aminé soufré. En outre, la méthionine joue un rôle important dans la synthèse de nombreuses protéines primordiales telles que la carnitine ou la mélatonine. La méthionine permet de dissoudre les graisses, et limite le dépôt de graisses dans le foie;La méthionine fortifie les ongles et aide à prévenir la perte de cheveux; La méthionine contribue à la formation du cartilage.

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Kindly Tips for amino acids in animal feed

Adding amino acids in animal feed meets the demand for animal protein, improving feed utilization. It may also reduce stress in animals. As a animal feed additive, it plays a significant effect for Amino acids, because of its  high price, it should be a reasonable choice, not to affect the quality of feed, reducing in economic losses.

1.It should be careful observe, identify and judge the packaging, appearance, odor, color, etc during the selection of such additives,  no use the product with doubting.

2. Amino acids are usually used in livestock feed additive, especially in the developmental stages of young animals, and sheep and other ruminants can use amino acids since the microbial synthesis,  there is no distinguish between amino acids and non-limiting limiting , generally do not use amino acid feed additive.  It is still controversial for Aquatic animal utilization of chemical synthesis of amino acids , therefore, It is better to carefull use aquatic feed.

3. During the use of amino acids in the feed, it should first consider the first limiting amino acid, and then turn to consider other limiting amino acids. Because there is a feature for animals use of amino acids that only the first limiting amino acids are satisfied, the second and the other limiting amino acids can get a better use. The first limiting amino acid lysine in pigs, the second limiting amino acid methionine; and the first limiting amino acid methionine chickens and other poultry, the second limiting amino acid lysine.

4. the amount of amino acids should be based on the content and its effective potency to convert.

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Identify methionine by sensory

Identify  methionine by sensory:

1. True Methionine occurs white or light yellow crystalline powder with reflective, but false methionine occurs yellow or gray, little crystalline;
2. True methionine occurs special smell, false methionine smells not pure;
3. True methionine tastes slightly sweet, non-astringent sense; Adulteration of non-sweet smell while having impurities feeling;
4. pure methionine touch creamy texture, fake feel more rough;
5. hydroxysteroid methionine is a brown powder or granular, with hydroxyl group special smell.
6. aluminum products or plastic spoon inserted into methionine feed, a few turns out, there is static,  but fake not.
7. A small sample was added into 100ML water, stirred five seconds and stand, true methionine can be completely dissolved, if not, fake methionine.

Ningxia Unisplendour Tianhua Methionine Co.,Ltd

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Metionina

En su forma natural la L-metionina es un aminoácido proteinogenico. Es uno de los aminoácidos esenciales y no puede ser sintetizados por el propio organismo. Por lo tanto, su ingesta adecuada a través de la dieta o mediante los suplementos alimenticios es de crucial importancia.

Compuestos de azufre están presentes en todos los seres vivos y tienen una variedad de funciones. Junto a la cisteína, la metionina es el único aminoácido con contenido de azufre, por ello la metionina juega un papel importante en la síntesis de muchas proteínas importantes, como la carnitina o la melatonina, igualmente interviene en la disoluciónde grasa y limita la acumulación de grasa en el hígado.

La metionina es una sustancia importante para la formación del cartílago

Para su formación el cartilago de las articulaciones necesita azufre. En el caso de que en el organismo tengamos poca disponibilidad de azufre, no existe ningún problema a largo plazo para las personas sanas, pero en las personas que sufren de artrosis, una deficiencia de azufre, sin embargo, puede tener un efecto negativo en el comienzo de la enfermedad, especialmente en el proceso de curación del tejido dañado.

En investigaciones recientes se ha demostrado que el cartílago de las personas sanas posee aproximadamente tres veces más azufre que el cartílago de los pacientes con artrosis. Otro problema es que muchos fármacos forman sulfato, es decir, las sales del ácido sulfúrico. Esta es también la razón por la que la demanda de azufre para los pacientes con artritis es particularmente alta.


MetioninaSe recomienda impulsar la producción de azufre en el organismo. Ahora bien, no se puede tomar «azufre» tan fácilmente en forma de suplemento nutricional; por ello lo aconsejable es tomar el aminoácido metionina, que especialmente en combinación con las vitaminas B, puede formar casi todos los compuestos que contienen azufre. Y por ello la metionina es de especial importancia para los siguientes tres casos: reduce la inflamación, es calmante y estimula la formación de las células del cartílago.

La metionina fortalece las uñas y nos ayuda contra la caída del cabello

Debido a su capacidad para formar cadenas que contienen azufre, que a su vez se conectan entre sí, la metionina es capaz de fortalecer la estructura del cabello y las uñas.En 2006, en el marco de un congreso dermatológico realizado en Florencia, se publicaron los resultados de un estudio en el que participaron pacientes con alopecia, en el mismo se pudo comprobar que la cantidad de cabellos que se encontraban en la fase de crecimiento dentro del grupo que consumía un combinado de aminoácidos y vitaminas del grupo B eran significativamente más altas que la del grupo control (placebo).

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Ningxia Unisplendour Tianhua Methionine Co.,Ltd

Tips for Animal Feeding by DL Methionine Feed Grade

                        

                               Tips for Animal Feeding by DL Methionine Feed Grade

During raising animals, farmers take care animal baby carefully, not only animal accommodation, daily diet, loss of appetite. So as a feed additive, synthetic amino acids can improve the quality of livestock and poultry, lysine added into broiler diets can improve meat quality. So,what are tips can be noticed in fed animals by feed grade methionine?

Common sense for feed grade methionine: Broiler adds 0.1 to 2.5%,hens adds 0.1 to 0.2%, egg preliminary 0.1% from 0.05% late egg, it is preferable to add 3 to 5% into chicken feed with beef tallow, lard, Soybean oil (7300,46.00,0.63%) and other fats. In pigs feed, methionine takes 50%  percentage of lysine, but, in broiler hens feed, it is necessary to add sufficient methionine. If soy meal (4552,2.00,0.04%) substituted by rapeseed cake(5160,46.00,0.90%), cotton seed cake , the amount of lysine will be increased by 20%; If soybean meal (3645, 18.00,0.50%) is substituted by fishmeal , the amount of lysine can be reduced by 20%.  During design formula for pigs feed, it is import to consider the breed of pig, different stages and  varieties of feed raw materials, in order to obtain a better feed efficiency.

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Methionine Applied in Animal Production

Methionine is essential amino acids in animal, it plays an import role in poultry growth. Now, we are talking about Methionine Applied in Animal Production.

1. Application of laying hens

Methionine have a good preventive effect on heat stress on laying hens . In summer put zinc methionine into hens diets supplemented with 200mg / kg, test confirmed that 200mg / kg zinc methionine  can enhance immunity and anti-stress capability for chicken, promote appetite, reducing egg broken, enhancing eggshell thickness, improve egg weight, egg production, feed efficiency and economic benefits.

2. Application of swine production

Zinc methionine, as a organic zinc with high bioavailability, has also been a certain application  in pig production. Effect of zinc methionine on growth performance, the results showed that dietary supplemented of zinc methionine 300,350,400mg / kg treatment group compared with daily intake 40mg / kg group, the control group was up 21%, 22.2%, 21.2% . And diarrhea rate three experimental groups compared with the control group were significantly different. Wang Naiying (1996) reported, adding fattening dietary zinc methionine, average daily gain of 9.7%, 3.3% and feed efficiency, and its slaughter rate and lean meat were increased.

3. Application in Ruminant Production

Because zinc methionine holds chemical stability, biological titer, digestible absorption, interference, toxicity characteristics, while its rumen function, it  prevents the degradation of rumen microbial methionine, but also to avoid the metal elemental zinc toxicity on rumen microorganisms and methionine zinc chelate and after reducing the amount of ammonia decomposition, to reduce intermediate links, thereby increasing the absorption of blood and protein content of amino acids, beneficial to ruminant production performance of the play.


Zinc methionine has obviously effect in terms of biological potency, stability, performance, or promote, disease treatment and prevention aspects of animal production than other forms of zinc source. In summary, adding zinc methionine for pigs, chickens, ruminant diets after, economic efficiency is very significant enhanced. We should rational use of zinc methionine based on the breeding characteristics of science in the future, it can obtain a more considerable economic benefits in animal husbandry .

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Lisa Zhang
Email: lisazhang@unischem.com
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Ningxia Unisplendour Tianhua Methionine Co.,Ltd

Low-protein amino acid–supplemented diets for growing pigs: Effect on expression of amino acid transporters, serum concentration, performance, and carcass composition

Pigs fed protein-bound AA appear to have a higher abundance of AA transporters for their absorption in the jejunum compared with the duodenum. However, there is limited data about the effect of dietary free AA, readily available in the duodenum, on the duodenal abundance of AA transporters and its impact on pig performance. Forty-eight pigs (24.3 kg initial BW) distributed in 4 treatments were used to evaluate the effect of the CP level and form (free vs. protein bound) in which AA are added to diets on the expression of AA transporters in the 3 small intestine segments, serum concentration of AA, and performance. Dietary treatments based on wheat and soybean meal (SBM) were 1) low-CP (14%) diet supplemented with l-Lys, l-Thr, dl-Met, l-Leu, l-Ile, l-Val, l-His, l-Trp, and l-Phe (LPAA); 2) as in the LPAA but with added l-Gly as a N source (LPAA+N); 3) intermediate CP content (16%) supplemented with l-Lys HCl, l-Thr, and dl-Met (MPAA); and 4) high-CP (22%) diet (HP) without free AA. At the end of the experiment, 8 pigs from LPAA and HP were sacrificed to collect intestinal mucosa and blood samples and to dissect the carcasses. There were no differences in ADG, ADFI, G:F, and weights of carcass components and some visceral organs between treatments. Weights of the large intestine and kidney were higher in HP pigs (P < 0.01). Expression of b0,+ in the duodenum was higher in pigs fed the LPAA compared with the HP diet (P = 0.036) but there was no difference in the jejunum and ileum. In the ileum, y+ L expression tended to be higher in pigs fed the LPAA diet (P = 0.098). Expression of b0,+ in LPAA pigs did not differ between the duodenum and the jejunum, but in HP pigs, the expression of all AA transporters was higher in the jejunum than in the duodenum or ileum (P < 0.05). The serum concentration of Arg, His, Ile, Leu, Phe, and Val was higher but serum Lys and Met were lower in pigs fed the HP diet (P < 0.05). These results indicate that LPAA can substitute up to 8 percentage units of protein in HP wheat–SBM diets without affecting pig performance; nonessential N does not seem to be limiting in very low-protein wheat–SBM diets for growing pigs. Also, the inclusion of free AA in the diet appears to affect their serum concentration and the expression of the AA transporter b0,+ in the duodenum of pigs.

Referenced by Internet


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DL-Метионин

DL-метионин кормовой, применяемый в порошкообразной форме, почти в три раза эффективнее усваивается организмом, чем такой же препарат в жидком виде. Нехватка веществ, содержащихся в DL - метионине, приводит к снижению аппетита, атрофии мускулов, анемии, ожирению печени. В результате, резко падает показатель продуктивности и набор веса. Яичный белок вырабатывается с замедлением, соответственно, снижается продуктивность. Кроме того, если в корме наблюдается нехватка витамина Е, птица заболевает дерматитом и дистрофией мышц. Препарат хорошо смешивается с кормами, поэтому его использование достаточно эффективно. Метионин безопасен для оборудования – он не вызывает порчи металлических частей оборудования в кормоцехах.

DL-метионин кормовой используется для обогащения полезными добавками комбикормов, премиксов, смесей при составлении рационов для животных. Дозируется препарат применительно возраста, вида, условий содержания. 

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How to Distinguish Methionine True or Not ?

                    How to Distinguish Methionine True or Not ?

DL Methionine is an essential amino acids that plays an important role in feed field. However, there is lots of fakes in methionine market. So, I would like to share some tips for your reference:

1.  Burn, do not leave residue, there is an smell of burnt feathers;

2.  Touch, there is a special smell methionine (hydroxysteroid special smell hydroxyl group) with true methionine;  a little sweet when taste, touched smothly not rough .

False methionine smell bad, such as ammonia or Aroma smell , feel rough, not creamy.

3. Dissolve: Take methionine around 1 gram , add distilled water 50 ml, stir gently, shaking, standing, solution clearly and no precipitation with real methionine; If not, it is false.

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DL Methionine Introduction

Methionine,an important amino acid species of animal feed, is an essential feed additive added into animal feed, which helps animals grow rapidly in a short time. It saves about 40% of the feed. In particular, feed poultry feed, methionine is the first limiting amino acid. Lacking of methionine for animal  will cause dysplasia, weight loss, liver and kidney function decline, muscle atrophy, deterioration. 1kg methionine  added into animal feed is  equivalent 50kg nutritional value of the meal (added in an amount of 0.05% to 0.2%).

Methionine is devided into DL- methionine, methionine hydroxy, hydroxy methionine calcium salts, N- hydroxymethyl methionine. In the feed industry, the demand for methionine is significant, particularly amino acids in nutritional feed additives, 60% of methionine, lysine 30%, about 10% of other amino acids. Methionine consumption structure, the feed additive is the largest consumer market.

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Ningxia Unisplendour Tianhua Methionine Co.,Ltd

DL-Methionine Factory Introduction

Established in 2009, Ningxia Unisplendour Tianhua Methionine Co.,Ltd also named Chongqing Unisplendour Tianhua Methionine Co.,Ltd before 2013 is located in Central Industrial Park, Zhongwei City Ningxia Hui Autonomous Region, China and has been specializing in the research, production and sales of feed grade DL Methionine.

In June of 2010, the plant with 10,000mt feed grade DL Methionine was put into operation.Since then, our company has been the only domestic manufacturer for feed grade DL Methionine.

In October of 2011, because of the breakthrough in the key technology of DL Methionine, our company got the prize of Science and Technology Progress awarded by China Petroleum and Chemical Industrial Federation.

In April of 2012, the 50,000 mt feed grade DL Methionine project was completed and put into operation.

In 2013, we moved our factory from Chongqing to Ningxia and changed our company name from Chongqing Unisplendour Tianhua Methionine Co.,Ltd to Ningxia Unisplendour Tianhua Methionine Co.,Ltd. It is expected that by June 2016, our production capacity will reach 100,000 mt per year. Therefore, our company is capable of ensuring a sustainable& stable supply of DL Methionine for its world wide customers.

Ningxia Unisplendour Tianhua Methionine Co.,Ltd looking forward our cooperation.

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Email: lisazhang@unischem.com

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